Establishment of European Initial Training Network (TOLLerant)15 October, 2014
Back to News

Call: Horizon 2020-Marie Curie actions-ITN-2014
Project: "Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach"
Acronym: TOLLerant
Coordinator: Francesco Peri
Duration: 48 months
Start Date: January 2015

The TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signalling by using synthetic and natural compounds and nanoparticles that interact selectively with some components (mainly MD-2 and CD14) of the TLR4 recognition system. TLR4 is an emerging molecular target related to an impressively broad spectrum of modern day disorders still lacking specific pharmacological treatment. These include autoimmune disorders, chronic inflammations, allergies, asthma, infectious and CNS diseases, and cancer.

Prof. Francesco Peri, Prof. Roman Jerala, European Initial Training Network (TOLLerant)The short-term scientific objective is to develop novel, non-toxic, synthetic and natural TLR4 modulators (agonists or antagonists) and to assess their therapeutic potential on animal models of TLR4-related acute and chronic pathologies. The long-term scientific objective is to develop a new generation of innovative, TLR4-based therapeutics, to be used as vaccine adjuvants, anti-sepsis agents, and anti-inflammatory agents to treat chronic inflammations (allergy, asthma).
The training programme will provide Early Stage Researchers (ESR) with broad competencies, experience and skills in the cutting-edge, inter-disciplinary research in the field of chemical biology related to the molecular mechanisms of innate immunity and inflammation. During the training, the young researchers will be supported by senior scientists to cultivate their scientific, entrepreneurial and inter-cultural mindset. The non-academic sector will be committed to provide ESRs with entrepreneurship and company management skills, in order to enhance their employability by the private sector or even to motivate them to create own start-up companies.
This network includes 8 academic and 2 industrial partners from Italy, Spain, Slovenia, Germany and Belgium. It will provide 13 positions for PhD students in Immunology, Chemistry, and Nanotechnology, beginning in early 2015.

Prospective candidates are encouraged (for now) to send an inquiry to either

Prof. Francesco Peri (University of Milan-Biococca, Milano,Italy) 
or Prof. Roman Jerala (National Institute of Chemistry, Ljubljana, Slovenia):