Mission Statement

For more than a century, studies of Gram-negative bacterial endotoxins have helped propel major advances in knowledge of mechanisms mediating innate immune recognition, responses, and resolution. While the revelations of the past two decades have underscored the diversity of “danger”-associated molecular patterns that trigger innate immune responses, the abundance and near ubiquity of endotoxins and their remarkable potency continue to distinguish these unique glycolipids.  These properties have sustained and expanded interest in the potential beneficial and harmful roles of endotoxins in an increasing array of physiologic and patho-physiologic settings. Progress during this time in the structural analyses of endotoxin molecules from an increasing array of Gram-negative bacteria and in genetic and biochemical mechanisms leading to synthesis of structurally distinct endotoxins have revealed novel aspects of bacterial evolution and adaptation and helped guide the design and development of new immune modulators

The mission of the International Endotoxin and Innate Immunity Society (IEIIS), as that of the International Endotoxin Society that preceded the IEIIS, is to promote the exchange of ideas and new data among investigators of endotoxin biology and innate immunity and to support and promote the career development of our younger and more junior colleagues. Key to our society’s evolution has been the role that endotoxin-related research played in the discovery and characterization of innate immune recognition and response systems directed not just at Gram-negative bacteria but all microbe- and danger-associated perturbations of homeostasis.

Our society is distinguished by its global international membership and unique in its integrated focus on the chemistry, biology, physiology, and translational biology of microbe (pathogen)-associated molecular patterns, including but not limited to Gram-negative bacterial endotoxins, and their interactions with innate immune recognition and response systems.

Our efforts to meet our mission are manifest in many ways, including (co-)sponsorship of regional, national, and international meetings, publication of manuscripts in the journal sponsored by the IEIIS, Innate Immunity, and less formal interactions through our society Newsletter and website (www.IEIIS.org). The latter are being modernized in anticipation of next year’s XIII biennial international meeting, a joint meeting with the Society for Leukocyte Biology, and efforts to increase the visibility and activity of the IEIIS in the periods between the biennial meetings.